Thursday, 17 May 2018

Vertebrates: Mammals

Welcome back to evolution of venom, in today’s blog topic, we will be covering mammals that use venom. A brief recap: we covered other venomous lizards and how they use venom.
 
Studies on venomous mammals are rare as many mammals do not use venom or have lost the ability to use or develop venom over the course of their evolution.

Shrews are small mole-like mammals that belong to the family Soricidae, Order Eulipotyphla. Shrews are about the size of a mouse, but are closely related to hedgehogs and moles and are the only mammals (besides vampire bats) to produce venomous saliva. They feed on insects and seed, but some have specialized in hunting in the water, living in snow, climbing trees, and living underground. Some species of shrews have developed venomous saliva from the saliva glands in their body, causing bites from the shrew can cause a paralysing effect on insects, snails and small mammals, but has little effect on humans unless they are allergies to shrew bites (Ligabue-Braun et al, 2012). Below is a picture of a Southern short-tailed shrew (Blarina brevicauda).
By Unknown
 
Platypus (Ornithorhynchus anatinus) is a semi-aquatic egg laying mammal that belongs to the family Ornithorhynchidae, Order Monotremata (sometime called Monotremes). Their appearance of a duck-billed, beaver-tailed, otter-footed mammal is unusual and baffled scientists when they first encountered it. Both female and male platypuses have spurs on their hind legs, but females lose their spurs during development (Whittington et al, 2010). The spurs on the male platypus are connected to venom-producing crural glands, forming a crural system. When attacked by another animal, the hind legs of the platypus are driven towards each other, causing the flesh of the attacking animal to be caught in-between the hind legs and receives venom from the spurs by repeated jabs. Venom from a platypus is not fatal toward humans, but can cause extreme amount to pain (Ligabue-Braun et al, 2012). Below is a picture of a platypus.
 
By Klaus - Flickr: Wild Platypus 4, CC BY-SA 2.0
 
Common vampire bat (Desmodus rotundus) is a small, leaf nose bat that belong to the family Phyllostomidae, Order Chiroptera. The Common vampire bat is a hematophagous specialist which means that they feed of the blood of other animals. They are one of the most social species of bats where males defending groups of females, bringing back food for the ones that miss out on feeding (mostly nursing mothers), and participate in social grooming. The Common vampire bat venomous saliva contains anticoagulant properties that prevent blood from clotting when feeding, a bat will find a host to feed (when they are asleep) and make a small incision with it teeth (causing no pain to the host) allowing the saliva to prevent blood from clotting and allowing the bat to drink until it is full. The saliva is not fatal to most animals, expect for chickens that may die of haemorrhage (Ligabue-Braun et al, 2012). Below is a picture of a common vampire bat.
 
Picture taken at Sangayan Island, Paracas National Reserve, Departamento Ica, Peru, in March 2005
 
In next week’s post, we will be covering amphibians that use venom. Below are the articles that were used in this week’s post.  
 
 
References
 
Ligabue-Braun, R., Verli, H. & Carlini, C.R. 2012, "Venomous mammals: A review", Toxicon, vol. 59, no. 7-8, pp. 680-695.
 
Whittington, C.M., Papenfuss, A.T., Locke, D.P., Mardis, E.R., Wilson, R.K., Abubucker, S., Mitreva, M., Wong, E.S.W., Hsu, A.L., Kuchel, P.W., Belov, K. & Warren, W.C. 2010, "Novel venom gene discovery in the platypus", Genome Biology, vol. 11, no. 9, pp. R95-R95


 

Thursday, 10 May 2018

Vertebrates: Venomous Lizards

Welcome back to evolution of venom, in today’s blog topic, we will be coving other reptiles that use venom. A brief recap: we covered on what vertebrates are, what are snakes and how they use their venom.
 
Venomous lizards are restricted to two species, the Gila Monster (Heloderma suspectum) and the Mexican beaded lizard (Heloderma horridum). The Gila Monster is a heavy, slow moving lizard and is the only venomous lizard in the United States. The Mexican beaded lizard is slightly larger than the Gila Monster and is found in Mexico. Both species are Helodermatids, which are large, stout- bodied lizard with short legs designed for digging and they have a large head with powerful jaws (West et al, 2014).
 
The venom glands are located in the lower jaw with enlarged, grooved teeth located above the glands. Their jaws are designed to bite on to their prey and maintain a vice grip on the prey. Their venom is mainly for defensive purpose and human deaths are rare, the venom mostly causes a drop in blood pressure causing hypotensive shock (West et al, 2014). Below are 2 images on what each lizard looks like.
Gila Monster (Heloderma suspectum)
Mexican beaded lizard (Heloderma horridum)
By David Rubin - originally posted to Flickr as 00254-20.07.2007-Zoo, CC BY 2.0, https://commons.wikimedia.org/w/index.php?curid=8350359
 
Komodo dragons (Varanus komodoensis) are the world’s largest lizard weighing up to 90 kg and a length of 3 m. It is found on five small islands in Eastern Indonesia. Komodo dragon’s saliva contain bacteria that can cause sepsis and infection allowing the Komodo dragon to follow the weaken prey until they collapsed and died from their infection. There is a debate on if the Komodo dragon’s saliva is venomous or not (Bull, 2010).
 
Komodo dragon (Varanus komodoensis)
By Mark Dumont - Flickr: There Be Dragons, CC BY 2.0, https://commons.wikimedia.org/w/index.php?curid=25935468
 
 
In next week blog, we will be covering mammals that use venom, below are the articles that were used in this week's blog.
 
References
Bull, J.J., Jessop, T.S. & Whiteley, M. 2010, "Deathly drool: evolutionary and ecological basis of septic bacteria in Komodo dragon mouths", PloS one, vol. 5, no. 6, pp. e11097


 
 

 


 

 
 

Thursday, 3 May 2018

Vertebrates: Snakes

Welcome back to evolution of venom, Today’s blog topic, we will be coving what vertebrates are and land/sea snakes that use venom. A brief recap: we covered bees, wasps, centipedes and moths and how they use their venom.

Vertebrates are animals that have a backbone or spinal column, a closed circulatory system, a heart divided into 2,3, or 4 chambers, and a brain enclosed in a cranium. There are 5 classes of vertebrates: birds, fish amphibians, reptiles and mammals (Vertebrate, 2017).

Snakes belong to the order Squamata (Scaled reptiles) which also includes lizards, but belong to the suborder Serpentes. Snakes have no limbs, eyelids or external ears, forked tongue that allows them to taste the air around themselves and a long slender body (snake, 2017). Venomous snakes have fangs located in their upper jaw which contain venom ducts that run along the inside of the fangs. Below is a diagram of the venom ducts of a snake.

Diagram of snake venom ducts by www.newtonsapple.org.uk

Venom is introduced to the human body in a number of ways, the most common way is a snakebite which leaves two puncture holes in the skin. Some venomous snakes spray venom at their prey from their mouth causing the venom to be introduced through the mouth or eyes. Depend on the species of snake, venom can cause blindness, severe pain, necrotic tissue, swelling and death (Warrell, 2015).
 
In next week’s blog, we will be covering more reptiles that use venom. Below are the articles used in this week’s blog post for more information about snake venom.

 References
snake. (2017). In Encyclopaedia Britannica, Britannica concise encyclopedia. [Online]. Chicago: Britannica Digital Learning.
Vertebrate. (2017). In P. Lagasse & Columbia University, The Columbia encyclopedia. (7th ed.). [Online]. New York: Columbia University Press.
 
Warrell, D.A. 2015;2016;, "Venomous animals", Medicine, vol. 44, no. 2, pp. 120-124


Picture Reference
http://www.newtonsapple.org.uk/wp-content/uploads/2014/08/venomous-snake-fangs-diagram.jp
 
 


Friday, 27 April 2018

Invertebrates:bees, wasps, centipedes and moths


Welcome back to evolution of venom, Today’s blog topic, we will be covering bees, wasps, centipedes and moths and how they use their venom. A brief recap: we covered cone snails, jellyfish, and sea urchins and how they use their venom.

Bees are flying insects that belong to the order Hymenoptera, superfamily Apoidea that produces honey and beeswax, they are known for their role in pollination and live mostly in large colonies (Danforth et al, 2006). Bee venom comes from the poison gland that contains a variety of toxins and chemicals, bee stings are dangerous to both humans and bees as the stinger that introduces the venom into the human’s system is torn from the abdomen causing the death of the bee. Some humans can have a severe reaction to bee venom causing shock and death (Warrell, 2015). Below is a diagram of a honey bee. 
Diagram of honeybee by exploringnature
 
Wasps are another flying insect that belongs to the order Hymenoptera, but belongs to the family Vespoidea. A majority of wasps are carnivores, feeding on grubs, spiders, and other insects. Many species of wasps live in solitary but they can live in social colonies with a queen, workers and drones with the worker wasps been sterile. Unlike bees who died after losing their stinger, wasps can use their stinger repeatedly (Wasps, 2017). Below is a diagram of a sterile worker wasp.
By WikipedianProlific at the English language Wikipedia, CC BY-SA 3.0.
 
Centipedes are arthropods belonging to the class Chilopoda, Phylum Arthropoda. Their body is made up of a flattened head with a trunk composed of segments (somites). The head has long antennas, jaws and two pairs of maxillae used for food handling. The appendages on the trunks first segment has claws that have been modified to allow poison glands to deliver venom to stun or kill prey (Centipedes, 2017). Below is a diagram of a centipede.
 
Diagram of a centipede by enchantedlearning.

 
Moths belong to the order Lepidoptera (same as butterflies), although most moths are not venomous, two families (Megalopygidae and Saturniidae) have had human deaths by these moths. The Lonomia obliqua (Giant silkworm moth) larval form has spines with venom that when broken, the venom enters the bloodstream causing mild nausea, burning pain and headache, then progresses to haematuria, bleeding from scars, and severe haemorrhagic syndrome (Spadacci-Morena, 2006). Below is a diagram of a Lonomia obliqua larval.
By Centro de Informações Toxicológicas de Santa Catarina
 
In next weeks’ blog, we be covering vertebrates that use venom. Below are the articles used in this week’s blog for more reading about these animals.
 
References 
Centipede. (2017). In P. Lagasse, & Columbia University, The Columbia encyclopedia (7th ed.). New York, NY: Columbia University Press.
Danforth, B.N., Sipes, S., Fang, J. & Brady, S.G. 2006, "The History of Early Bee Diversification Based on Five Genes Plus Morphology", Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 41, pp. 15118-15123.
Spadacci-Morena, D.D., Soares, M.A.M., Moraes, R.H.P., Sano-Martins, I.S. & Sciani, J.M. 2016, "The urticating apparatus in the caterpillar of Lonomia obliqua (Lepidoptera: Saturniidae)", Toxicon : official journal of the International Society on Toxinology, vol. 119, pp. 218-224.
Warrell, D.A. 2015;2016;, "Venomous animals", Medicine, vol. 44, no. 2, pp. 120-124
Wasp. (2017). In P. Lagasse & Columbia University, The Columbia encyclopedia. (7th ed.).
Picture references



 

 
 
 
 
 


 




 
 
 
 
 

 
 




 
 
 
 
 
 
 
 
 

 
 
 

Thursday, 12 April 2018

Invertebrates: cone snails, jellyfish, and sea urchins


Welcome back to evolution of venom, Today’s blog topic, we will be covering the cone snail, jellyfish and sea urchins and how they use their venom.

Cone snails are marine gastropods belong to the family Conidae that prey on worms, molluscs and fish. Cone snails hunt by using their siphon to track prey, they use their proboscis to shoot a radula tooth to inject venom in the prey. They prey is immediate paralysed, allowing the snail to swallow the prey whole (Dutertre et al, 2014). Below is a diagram of a cone snail and how they hunt fish.
Anatomy of a cone snail and their hunting strategy by Ocean’s treasure  


Jellyfish are soft-bodied invertebrates that belong to the phylum Cnidaria, they mostly feed on small fish and prawns. Jellyfish float in the water and rely on their venomous tentacles to catch prey or defend themselves from other predators (Warrell, 2015). The tentacles have over a million sting capsules that when they come into contact with prey, they release small harpoons into the prey and bring it closer to them to eat (Junghanss & Bodio, 2006). Below is a diagram of a box sea jelly.

Anatomy of a box sea jelly by Ocean’s treasure 


Sea urchins are spiny echinoderms that belong to the class Echinoidea. Their shells are round and spiny, with the spines and tube feet helping them move across the ocean floor. Sea urchins mostly feed on algae, but will feed on slow moving animals. Their venom comes from their spines that when threatened or step on, the spines become embedded in the skin, causing extreme pain (Warrell, 2015). Below is a diagram of a sea urchin.
Anatomy of a sea urchin by Ocean’s treasure 
 

Next week blog, we will be covering bee’s, wasps, centipedes and moths that use venom. Below the articles used in this week blog for more reading at their venom.
 
Article references
Dutertre, S., Jin, A., Alewood, P. & Lewis, R. 2014, "Intraspecific variations in Conus geographus defence-evoked venom and estimation of the human lethal dose", TOXICON, vol. 91, pp. 135-144
 
Dutertre, S., Jin, A., Vetter, I., Hamilton, B., Sunagar, K., Lavergne, V., Dutertre, V., Fry, B., Antunes, A., Venter, D., Alewood, P. & Lewis, R. 2014, "Evolution of separate predation- and defence-evoked venoms in carnivorous cone snails", NATURE COMMUNICATIONS, vol. 5, no. 3521, pp. 3521-9
 
Warrell, D.A. 2015;2016;, "Venomous animals", Medicine, vol. 44, no. 2, pp. 120-124
 
Junghanss, T. & Bodio, M. 2006, "Medically Important Venomous Animals: Biology, Prevention, First Aid, and Clinical Management", Clinical Infectious Diseases, vol. 43, no. 10, pp. 1309-1317
 

 
 
 

 
 
 
 

 
 
 
 

 


 



 


 



 
 
 
 


Thursday, 5 April 2018

Invertebrate: spiders


Hello again. Welcome back to Evolution of venom. Today blog topic, we will be covering more about invertebrates that use venom. A recap from the last blog: we covered what an invertebrate is and scorpions and their venom.
 
Spiders belong to the order Araneae that is a part of the arachnid’s family, that includes scorpions and ticks. Below is a diagram of the internal anatomy of a female two-lunged spider with the venom gland located just below the simple eye.

Internal anatomy of a female two-lunged spider by John Henry (1996)
 

Spider venom is introduced to the body by the fangs connected to the venom gland, some species of spider fangs are too small to penetrate human skin or their venom is too weak to produce any effects (Junghanss & Bodio, 2006). Brown/black widows, wandering spiders and funnel web spiders have neurotoxic venom that cause vomiting, fever, muscle spasms, sweating, cramping pains and alteration in blood pressure and heart rate (Warrell, 2015-2016). Spider venom is used to make anti-venom that is used for extreme cases depending on which spider species caused the bite (Hardy, Cochrane & Allavena, 2014).

In next weeks’ blog, we be covering the cone snail, jellyfish and sea urchins that use venom. Below are three articles about spider venom used for this post.

 References
Hardy, M.C., Cochrane, J. & Allavena, R.E. 2014, "Venomous and Poisonous Australian Animals of Veterinary Importance: A Rich Source of Novel Therapeutics", BioMed Research International, vol. 2014, pp. 1-12.
Junghanss, T. & Bodio, M. 2006, "Medically Important Venomous Animals: Biology, Prevention, First Aid, and Clinical Management", Clinical Infectious Diseases, vol. 43, no. 10, pp. 1309-1317
Warrell, D.A. 2015;2016;, "Venomous animals", Medicine, vol. 44, no. 2, pp. 120-124.

Picture reference
Spider_internal_anatomy.png: John Henry Comstock Conversion to SVG: Pbroks13 (Ryan Wilson) (talk)  -  Anatomical information and original diagram from The Spider Book (1912, 1920) by John Henry Comstock Additional anatomical information from Biology of Spiders (1996) by Rainer F. Foelix
 

 
 

 
 

Thursday, 29 March 2018

Inverebrate: Scorpions


Blog post 4
Hello again, welcome back evolution of venom. Today’s blog topic will be covering one of the invertebrates that use venom. A recap from last blog: a third theory about how venom evolve by gene duplication and which animal lineages evolved venom (exception of birds).
 
First off, what is an invertebrate? An invertebrate is considered to be an animal without a backbone with scorpions, spiders, insects like bees and wasps, cephalopods, molluscs, and jellyfish (Casewell, 2017).
 
Scorpions
Scorpions belong to the order Scorpionida that is a part of the arachnid’s family which is the same family that spiders come from (The Columbia encyclopedia, 2008). The body of the scorpion is comprised of the prosoma (head), a segmented opisthosoma (body), six appendages on the body, two pedipads (claws), a mesosoma (Tail) and a narrow sting at the end on the tail (The Columbia encyclopedia, 2017).

Venom from the gland is forced down and out of the tip of the stinger by the muscles around the gland (The Columbia encyclopedia, 2008). Scorpion venom affects human differently depending on the species of scorpions as symptoms can occur in five hours including nausea, sweating, and vomiting. As the venom affects the nervous system, more dangerous symptoms are respiratory problems, multi-system-organ failure and death (Petricevich, 2010).
 By Shantanu Kuveskar - Own work, CC BY-SA 4.0, https://commons.wikimedia.org/w/index.php?curid=38768394
 
In next week’s blog, we be covering other invertebrates that use venom. Below are the articles used in this week’s blog if anyone wants to read more about scorpions.

 
References  
Casewell, N. 2017, "Evolution: Gene Co-option Underpins Venom Protein Evolution", CURRENT BIOLOGY, vol. 27, no. 13, pp. R647-R649.
 
Petricevich, V.L. 2010, "Scorpion Venom and the Inflammatory Response", Mediators of Inflammation, vol. 2010, pp. 1-16.
 
scorpion. (2017). In P. Lagasse & Columbia University, The Columbia encyclopedia. (7th ed.). [Online]. New York: Columbia University Press. Available from: https://elibrary.jcu.edu.au/login?url=https://search.credoreference.com/content/topic/scorpion?institutionId=429 [Accessed 30 March 2018].
 
scorpion. (2008). In Philip's encyclopedia. [Online]. London: Philip's. Available from: https://elibrary.jcu.edu.au/login?url=https://search.credoreference.com/content/entry/philipency/scorpion/0?institutionId=429 [Accessed 30 March 2018].
 

Wednesday, 21 March 2018

Venom Evolution Part 2


Hello again. Welcome back to Evolution of venom. Today blog topic, we will be covering venom evolution part 2. A recap from the last blog: Two theories about venom evolution were covered, positive Darwinian selection and macro evolutionary diversification (biosynthesis and sequestration).
 
Today’s theory about venom evolution is gene duplication. Gene duplication is where a part of the DNA is duplicated and mutates without leaving any harmful consequences to the animal and may increase the fitness of the animal (Fatima, E. 2013). Some of the DNA duplicates may be retained by natural selection or genetic drift while the rest of the duplicates are lost to mutations (Wong and Belov, 2012).
 
Many of the venom toxins may have evolve by ‘birth & death process’ cause by gene evolution and gene duplication, where a gene with a normal ‘physiological’ body protein is duplicate and the duplicate gene is expressed in the venom gland or other venomous tissue (Casewell et al. 2013). Over time venom has evolved in a few animal lineages from invertebrates and vertebrates with the exception of birds (Casewell, N. 2017).

In next week’s blog, we will be covering some of the invertebrates that can use venom. Below are four journal articles if anyone want to read more about gene duplication.
 
References
Casewell, N. 2017, "Evolution: Gene Co-option Underpins Venom Protein Evolution", CURRENT BIOLOGY, vol. 27, no. 13, pp. R647-R649.
 
Casewell, N.R., Wüster, W., Vonk, F.J., Harrison, R.A. & Fry, B.G. 2013, "Complex cocktails: The evolutionary novelty of venoms", Trends in Ecology and Evolution, vol. 28, no. 4, pp. 219-229
 
Fatima, E. 2013, "Venom evolution: Genetic and external factors", Resonance, vol. 18, no. 3, pp. 287-288
 
Wong, E.S.W. & Belov, K. 2012, "Venom evolution through gene duplications", Gene, vol. 496, no. 1, pp. 1-7.